GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Srebf1 | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of SREBF1 protein | PMID:23647015 | Srebf1 | multiple interactions | EXP | | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]; 4-(2-aminoethyl)benzenesulfonylfluoride inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]; Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; exoenzyme C3, Clostridium botulinum inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]; fatostatin inhibits the reaction [Glucose promotes the reaction [SREBF1 protein binds to TGFB1 promoter]]; fatostatin inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein]; Glucose promotes the reaction [SREBF1 protein binds to FASN promoter]; Glucose promotes the reaction [SREBF1 protein binds to TGFB1 promoter]; Glucose results in increased activity of and results in increased cleavage of SREBF1 protein; L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; PD168393 inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; RTKI cpd inhibits the reaction [Glucose results in increased activity of and results in increased cleavage of SREBF1 protein]; SREBF1 protein affects the reaction [Glucose results in increased expression of TGFB1 mRNA]; Wortmannin inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]; Y 27632 inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein] | PMID:22031849 PMID:23647015 | Srebf1 | increases expression | ISO | SREBF1 (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of SREBF1 mRNA; Glucose results in increased expression of SREBF1 protein | PMID:23319015 PMID:23647015 | Srebf1 | increases expression | ISO | Srebf1 (Mus musculus) | 6480464 | CTD | Glucose results in increased expression of SREBF1 mRNA; Glucose results in increased expression of SREBF1 protein | PMID:10913129 PMID:15066988 PMID:23090186 | Srebf1 | multiple interactions | ISO | SREBF1 (Homo sapiens) | 6480464 | CTD | [INS protein co-treated with Glucose] results in increased expression of SREBF1 mRNA; Allopurinol inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]]; dorsomorphin inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]; L 709049 analog inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]]; platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]; platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; Quercetin inhibits the reaction [Glucose results in increased expression of SREBF1 protein]; SRT1720 inhibits the reaction [[INS protein co-treated with Glucose] results in increased expression of SREBF1 mRNA]; STO 609 inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 mRNA]] | PMID:19724016 PMID:23319015 PMID:23647015 | Srebf1 | multiple interactions | ISO | Srebf1 (Mus musculus) | 6480464 | CTD | resveratrol inhibits the reaction [Glucose results in increased expression of SREBF1 protein] | PMID:23090186 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |