GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | INSR | decreases degradation | EXP | | 6480464 | CTD | Glucose results in decreased degradation of INSR mRNA | PMID:7826318 | INSR | decreases expression | EXP | | 6480464 | CTD | Glucose results in decreased expression of INSR protein; Glucose results in decreased expression of INSR protein modified form | PMID:24262486 | INSR | increases expression | EXP | | 6480464 | CTD | Glucose results in increased expression of INSR mRNA | PMID:7826318 | INSR | increases phosphorylation | EXP | | 6480464 | CTD | Glucose results in increased phosphorylation of INSR protein | PMID:7826318 | INSR | multiple interactions | EXP | | 6480464 | CTD | Catechin inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]; Catechin inhibits the reaction [Glucose results in decreased expression of INSR protein]; Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; PARP1 protein affects the reaction [Glucose inhibits the reaction [INS protein results in increased phosphorylation of INSR protein]]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein modified form]; Plant Extracts inhibits the reaction [Glucose results in decreased expression of INSR protein] | PMID:21031461 PMID:24262486 | INSR | multiple interactions | ISO | Insr (Rattus norvegicus) | 6480464 | CTD | 3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein]; Catechin inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein]; Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein | PMID:29981789 | | ||||||||||||||||||||||
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