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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDGlucose results in decreased expression of DDIT3 mRNA

PMID:17178593
increases expressionEXP 6480464CTDGlucose deficiency results in increased expression of DDIT3 mRNA, Glucose results in increased expression of DDIT3 mRNA, Glucose results in increased expression of DDIT3 protein

PMID:27226639, PMID:28482072, PMID:30076216
multiple interactionsEXP 6480464CTD2-aminoethoxydiphenyl borate inhibits the reaction [Glucose results in increased expression of DDIT3 protein], DDIT3 affects the reaction [Glucose results in decreased expression of PPARGC1A mRNA], Gadolinium inhibits the reaction [Glucose results in increased expression of DDIT3 protein], Glucose inhibits the reaction [DDIT3 protein binds to PPARGC1A promoter], TRPM7 protein affects the reaction [Glucose results in increased expression of DDIT3 protein], waixenicin A inhibits the reaction [Glucose results in increased expression of DDIT3 protein]

PMID:28482072, PMID:30076216
decreases expressionISORGD:623916480464CTDGlucose results in decreased expression of DDIT3 mRNA

PMID:24349266
increases expressionISORGD:623916480464CTDGlucose deficiency results in increased expression of DDIT3 protein

PMID:21337367
multiple interactionsISORGD:691656480464CTD[Galactose co-treated with Glucose deficiency] promotes the reaction [leflunomide results in increased expression of DDIT3 protein]

PMID:29427785
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.