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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620665
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fasn
Name: fatty acid synthase
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fasnincreases expressionEXP 6480464CTDGlucose results in increased expression of FASN proteinPMID:23647015
Fasnmultiple interactionsEXP 6480464CTDAllopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; Glucose promotes the reaction [SREBF1 protein binds to FASN promoter]; Quercetin inhibits the reaction [Glucose results in increased expression of FASN protein]PMID:22031849 PMID:23647015
Fasnincreases expressionISOFASN (Homo sapiens)6480464CTDGlucose results in increased expression of FASN proteinPMID:18482975 PMID:23647015
Fasnincreases expressionISOFasn (Mus musculus)6480464CTDGlucose results in increased expression of FASN mRNAPMID:15066988
Fasnmultiple interactionsISOFASN (Homo sapiens)6480464CTD[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides; [INS protein co-treated with Glucose] results in increased expression of FASN mRNA; [Resveratrol results in increased activity of SIRT1 protein] inhibits the reaction [[Glucose results in increased expression of FASN protein] which results in increased abundance of Triglycerides]; Allopurinol inhibits the reaction [Glucose results in increased expression of FASN protein]; PRKAA2 protein promotes the reaction [SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]]; Quercetin inhibits the reaction [Glucose results in increased expression of FASN protein]; SIRT1 protein inhibits the reaction [Glucose results in increased expression of FASN protein]; SRT1720 inhibits the reaction [[INS protein co-treated with Glucose] results in increased expression of FASN mRNA]PMID:18482975 PMID:19724016 PMID:23647015
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