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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 619570
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK3
Name: mitogen-activated protein kinase 3
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK3decreases phosphorylationEXP 6480464CTDGlucose results in decreased phosphorylation of MAPK3 proteinPMID:20200188
MAPK3increases activityEXP 6480464CTDGlucose deficiency results in increased activity of MAPK3 proteinPMID:17309078
MAPK3increases phosphorylationEXP 6480464CTDGlucose results in increased phosphorylation of MAPK3 proteinPMID:18057711 PMID:19557821 PMID:20962025 PMID:23690508 PMID:38000455
MAPK3multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]]; 4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; CAT inhibits the reaction [Glucose deficiency results in increased activity of MAPK3 protein]; Catechin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; epigallocatechin gallate inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; EUK-134 inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Fulvestrant inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]]; Glucose deficiency results in increased expression of and results in increased phosphorylation of MAPK3 protein; Glucose promotes the reaction [Bupivacaine results in increased phosphorylation of MAPK3 protein]; Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein; Heparin analog inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Luteolin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Phytic Acid inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Quercetin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Rutin inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Glucose deficiency results in increased activity of MAPK3 protein]PMID:17309078 PMID:18057711 PMID:19557821 PMID:20962025 PMID:22162761 PMID:34060177 PMID:34580807 PMID:38000455
MAPK3affects phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDGlucose affects the phosphorylation of MAPK3 proteinPMID:19020779
MAPK3increases expressionISOMapk3 (Rattus norvegicus)6480464CTDGlucose results in increased expression of MAPK3 protein modified formPMID:20860660
MAPK3increases phosphorylationISOMapk3 (Rattus norvegicus)6480464CTDGlucose results in increased phosphorylation of MAPK3 proteinPMID:16572112 PMID:19861503 PMID:20060012 PMID:24971582 PMID:31838053
MAPK3increases phosphorylationISOMapk3 (Mus musculus)6480464CTDGlucose results in increased phosphorylation of MAPK3 proteinPMID:33631230
MAPK3multiple interactionsISOMapk3 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; [sphingosine 1-phosphate co-treated with Glucose] results in increased expression of MAPK3 protein modified form; cinnamaldehyde inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; diphenyleneiodonium inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; diphenyliodonium inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; farrerol inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein; Hydrogen Peroxide promotes the reaction [Glucose results in increased expression of MAPK3 protein modified form]; MAPK3 protein promotes the reaction [NRG1 protein results in increased transport of Glucose]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Quercetin promotes the reaction [Glucose results in increased expression of MAPK3 protein modified form]]; PRKCB protein affects the reaction [Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Quercetin promotes the reaction [Glucose results in increased expression of MAPK3 protein modified form]; Resveratrol inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; ruboxistaurin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Superoxides affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Glucose results in increased expression of MAPK3 protein modified form]; U 0126 inhibits the reaction [Quercetin promotes the reaction [Glucose results in increased expression of MAPK3 protein modified form]]PMID:14711829 PMID:16572112 PMID:19587355 PMID:20060012 PMID:20860660 PMID:22406263 PMID:24971582 PMID:31838053
MAPK3multiple interactionsISOMapk3 (Mus musculus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 3-((6-(2-methoxyphenyl)pyrimidin-4-yl)amino)phenyl)methane sulfonamide inhibits the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; [Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK3 protein; CDK9 protein affects the reaction [Glucose results in increased phosphorylation of MAPK3 protein]; Glucose inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Glucose promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; Glucose results in increased phosphorylation of and results in increased activity of MAPK3 protein; Resveratrol inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK3 protein]; Silymarin promotes the reaction [Glucose promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]]; SOD1 protein inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased phosphorylation of MAPK3 protein]PMID:18310510 PMID:19228841 PMID:19303870 PMID:24682241 PMID:29753610 PMID:30098273 PMID:33631230
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