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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 14043101
Species: Sus scrofa
RGD Object: Gene
Symbol: INS
Name: insulin
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
INSincreases transportEXP 6480464CTDINS protein results in increased transport of GlucosePMID:8048502
INSmultiple interactionsEXP 6480464CTDINS protein promotes the reaction [AZ 002 results in increased uptake of Glucose]; oxophenylarsine inhibits the reaction [INS protein results in increased transport of Glucose]; Sirolimus inhibits the reaction [Glucose results in increased secretion of INS protein]PMID:20622751 PMID:8048502 PMID:8699633
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