GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Edn1 | decreases expression | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | Glucose results in decreased expression of EDN1 mRNA | PMID:31655124 | Edn1 | increases expression | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | Glucose results in increased expression of EDN1 protein | PMID:26891083 | Edn1 | increases expression | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | Glucose results in increased expression of EDN1 mRNA; Glucose results in increased expression of EDN1 protein | PMID:16428915 PMID:20960276 PMID:24376792 | Edn1 | multiple interactions | ISO | Edn1 (Rattus norvegicus) | 6480464 | CTD | Glucose affects the reaction [EDN1 protein affects the abundance of and affects the localization of Calcium]; HIF1A protein affects the reaction [Glucose results in increased expression of EDN1 protein]; MIR217 mRNA affects the reaction [Glucose results in increased expression of EDN1 protein]; resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]; SIRT1 protein affects the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 protein]] | PMID:12821678 PMID:26891083 | Edn1 | multiple interactions | ISO | EDN1 (Homo sapiens) | 6480464 | CTD | carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; carvedilol inhibits the reaction [Glucose results in increased expression of EDN1 protein]; CAT protein inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; CEBPA protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]; CEBPA protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]; CEBPB protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]; CEBPB protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]; CEBPD protein affects the reaction [Glucose results in increased expression of and results in increased secretion of EDN1 protein]; CEBPD protein affects the reaction [Glucose results in increased expression of EDN1 mRNA]; diphenyleneiodonium inhibits the reaction [Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]]; Glucose promotes the reaction [CEBPA protein binds to EDN1 promoter]; Glucose promotes the reaction [CEBPB protein binds to EDN1 promoter]; Glucose promotes the reaction [CEBPD protein binds to EDN1 promoter]; Glucose promotes the reaction [EDN1 protein results in increased chemical synthesis of Inositol 1,4,5-Trisphosphate]; pyrazolanthrone inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; resveratrol inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; SB 203580 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA]; U 0126 inhibits the reaction [Glucose results in increased expression of EDN1 mRNA] | PMID:16428915 PMID:20691780 PMID:20960276 PMID:24376792 | | ||||||||||||||||||||||
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