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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732502
Species: Homo sapiens
RGD Object: Gene
Symbol: MAPK1
Name: mitogen-activated protein kinase 1
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MAPK1increases phosphorylationEXP 6480464CTDFenretinide results in increased phosphorylation of MAPK1 proteinPMID:16407847 PMID:25246272
MAPK1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; [IL24 protein co-treated with Fenretinide] results in increased phosphorylation of MAPK1 protein; Acetylcysteine inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; BI D1870 inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; bisindolylmaleimide I inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; Butylated Hydroxyanisole inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Fenretinide results in increased phosphorylation of MAPK1 protein]PMID:15580305 PMID:16407847 PMID:25246272
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