GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727844
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Gpr135
Name: G protein-coupled receptor 135
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:7362496480464CTDFenretinide results in increased expression of GPR135 mRNA

PMID:28973697
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.