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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 62396
Species: Mus musculus
RGD Object: Gene
Symbol: Ddit3
Name: DNA-damage inducible transcript 3
Acc ID: CHEBI:42588
Term: 4-hydroxyphenyl retinamide
Definition: A retinoid obtained by formal condensation of the carboxy group of all-trans retinoic acid and the anilino group of 4-hydroxyaniline. Synthetic retinoid agonist. Antiproliferative, antioxidant and anticancer agent with a long half-life in vivo. Apoptotic effects appear to be mediated by a mechanism distinct from that of 'classical' retinoids.
Chemical ID: MESH:D017313
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ddit3increases expressionISODDIT3 (Homo sapiens)6480464CTDFenretinide results in increased expression of DDIT3 mRNA; Fenretinide results in increased expression of DDIT3 proteinPMID:15958647 PMID:16671099 PMID:16972258 PMID:17273769 PMID:17353921
Ddit3multiple interactionsISODDIT3 (Homo sapiens)6480464CTD4-((4-(4-ethylphenyl)-2,2-dimethyl-(2H)-thiochromen-6-yl)ethynyl)benzoic acid inhibits the reaction [Fenretinide results in increased expression of DDIT3 protein]; AGN 193109 inhibits the reaction [Fenretinide results in increased expression of DDIT3 protein]; Fenretinide promotes the reaction [DDIT3 protein results in increased expression of TNFRSF10B mRNA]; pyrrolidine dithiocarbamic acid inhibits the reaction [Fenretinide results in increased expression of DDIT3 protein]PMID:16972258 PMID:17273769
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