Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730870
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP1A1
Name: cytochrome P450 family 1 subfamily A member 1
Acc ID: CHEBI:42491
Term: flavone
Definition: The simplest member of the class of flavones that consists of 4H-chromen-4-one bearing a phenyl substituent at position 2.
Chemical ID: MESH:C043562
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP1A1decreases activityEXP 6480464CTDflavone results in decreased activity of CYP1A1 proteinPMID:21053930 PMID:31655123
CYP1A1increases expressionEXP 6480464CTDflavone results in increased expression of CYP1A1 mRNA; flavone results in increased expression of CYP1A1 proteinPMID:15890477
CYP1A1multiple interactionsEXP 6480464CTDflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; flavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]PMID:17090139
CYP1A1increases expressionISOCyp1a1 (Mus musculus)6480464CTDflavone results in increased expression of CYP1A1 mRNAPMID:20930378
Go Back to source page   Continue to Ontology report