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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69210
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP7A1
Name: cytochrome P450 family 7 subfamily A member 1
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP7A1decreases expressionISOCyp7a1 (Rattus norvegicus)6480464CTDEmodin results in decreased expression of CYP7A1 mRNA; Emodin results in decreased expression of CYP7A1 proteinPMID:28161596
CYP7A1multiple interactionsISOCyp7a1 (Rattus norvegicus)6480464CTD[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of CYP7A1 proteinPMID:35753641
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