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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10823
Species: Mus musculus
RGD Object: Gene
Symbol: Jak2
Name: Janus kinase 2
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jak2decreases phosphorylationISOJAK2 (Homo sapiens)6480464CTDEmodin results in decreased phosphorylation of JAK2 proteinPMID:23848338
Jak2multiple interactionsISOJAK2 (Homo sapiens)6480464CTDEmodin inhibits the reaction [IL6 protein results in increased phosphorylation of JAK2 protein]PMID:23848338
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