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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10368
Species: Mus musculus
RGD Object: Gene
Symbol: Abcc2
Name: ATP-binding cassette, sub-family member 2
Acc ID: CHEBI:42223
Term: emodin
Definition: A trihydroxyanthraquinone that is 9,10-anthraquinone which is substituted by hydroxy groups at positions 1, 3, and 8 and by a methyl group at position 6. It is present in the roots and barks of numerous plants (particularly rhubarb and buckthorn), moulds, and lichens. It is an active ingredient of various Chinese herbs.
Chemical ID: MESH:D004642
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Abcc2decreases expressionEXP 6480464CTDEmodin results in decreased expression of ABCC2 mRNAPMID:30517764
Abcc2decreases expressionISOAbcc2 (Rattus norvegicus)6480464CTDEmodin results in decreased expression of ABCC2 mRNA; Emodin results in decreased expression of ABCC2 proteinPMID:28161596
Abcc2increases expressionISOAbcc2 (Rattus norvegicus)6480464CTDEmodin results in increased expression of ABCC2 mRNAPMID:19549930
Abcc2multiple interactionsISOAbcc2 (Rattus norvegicus)6480464CTD[2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in decreased expression of ABCC2 protein; [2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucopyranoside co-treated with Emodin] results in increased expression of ABCC2 proteinPMID:35753641
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