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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353911
Species: Homo sapiens
RGD Object: Gene
Symbol: OGG1
Name: 8-oxoguanine DNA glycosylase
Acc ID: CHEBI:42068
Term: idarubicin
Definition: An anthracycline antibiotic that has formula 497.49392.
Chemical ID: MESH:D015255
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
OGG1decreases expressionISOOgg1 (Mus musculus)6480464CTDIdarubicin results in decreased expression of OGG1 mRNA; Idarubicin results in decreased expression of OGG1 proteinPMID:28973540
OGG1multiple interactionsISOOgg1 (Mus musculus)6480464CTDDexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 mRNA]; Dexrazoxane inhibits the reaction [Idarubicin results in decreased expression of OGG1 protein]PMID:28973540
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