GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Akr1c3 | decreases response to substance | ISO | AKR1C3 (Homo sapiens) | 6480464 | CTD | AKR1C3 protein results in decreased susceptibility to Daunorubicin | PMID:29992508 PMID:33025066 PMID:35972551 | Akr1c3 | increases metabolic processing | ISO | AKR1C3 (Homo sapiens) | 6480464 | CTD | AKR1C3 protein results in increased metabolism of Daunorubicin; AKR1C3 results in increased metabolism of Daunorubicin | PMID:20837989 PMID:32588086 PMID:33025066 | Akr1c3 | increases reduction | ISO | AKR1C3 (Homo sapiens) | 6480464 | CTD | AKR1C3 protein results in increased reduction of Daunorubicin | PMID:33025066 PMID:35972551 | Akr1c3 | multiple interactions | ISO | AKR1C3 (Homo sapiens) | 6480464 | CTD | [AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol; [AKR1C3 protein results in increased reduction of Daunorubicin] which results in increased abundance of daunorubicinol; [Tretinoin results in decreased activity of AKR1C3 protein] which results in increased susceptibility to Daunorubicin; dinaciclib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [[AKR1C3 protein results in increased reduction of Daunorubicin] which results in increased abundance of daunorubicinol]; enasidenib inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; enasidenib inhibits the reaction [AKR1C3 protein results in increased reduction of Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in decreased susceptibility to Daunorubicin]; midostaurin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin]; NVP-BKM120 inhibits the reaction [AKR1C3 protein results in increased reduction of and results in decreased susceptibility to Daunorubicin]; Tretinoin inhibits the reaction [[AKR1C3 protein results in increased metabolism of Daunorubicin] which results in increased abundance of daunorubicinol]; Tretinoin inhibits the reaction [AKR1C3 protein results in increased metabolism of Daunorubicin] | PMID:29992508 PMID:30703376 PMID:32588086 PMID:33025066 PMID:35972551 | | ||||||||||||||||||||||
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