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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620683
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Rps6kb1
Name: ribosomal protein S6 kinase B1
Acc ID: CHEBI:41977
Term: daunorubicin
Definition: A natural product found in Actinomadura roseola.
Chemical ID: MESH:D003630
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Rps6kb1decreases expressionEXP 6480464CTDDaunorubicin results in decreased expression of RPS6KB1 mRNAPMID:28099878
Rps6kb1increases phosphorylationISORPS6KB1 (Homo sapiens)6480464CTDDaunorubicin results in increased phosphorylation of RPS6KB1 proteinPMID:21898527
Rps6kb1multiple interactionsISORPS6KB1 (Homo sapiens)6480464CTDSirolimus inhibits the reaction [Daunorubicin results in increased phosphorylation of RPS6KB1 protein]PMID:21898527
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