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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10813
Species: Mus musculus
RGD Object: Gene
Symbol: Insr
Name: insulin receptor
Acc ID: CHEBI:41941
Term: (3,4-dihydroxyphenyl)acetic acid
Definition: A dihydroxyphenylacetic acid having the two hydroxy substituents located at the 3- and 4-positions. It is a metabolite of dopamine.
Chemical ID: MESH:D015102
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Insrmultiple interactionsISOInsr (Rattus norvegicus)6480464CTD3,4-Dihydroxyphenylacetic Acid inhibits the reaction [Glucose results in decreased expression of and results in decreased phosphorylation of INSR protein]; 3,4-Dihydroxyphenylacetic Acid results in increased expression of and results in increased phosphorylation of INSR proteinPMID:29981789
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