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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736173
Species: Mus musculus
RGD Object: Gene
Symbol: Becn1
Name: beclin 1, autophagy related
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Becn1decreases methylationEXP 6480464CTDDiethylstilbestrol results in decreased methylation of BECN1 promoterPMID:30153466
Becn1increases expressionEXP 6480464CTDDiethylstilbestrol results in increased expression of BECN1 mRNA; Diethylstilbestrol results in increased expression of BECN1 proteinPMID:30153466
Becn1multiple interactionsEXP 6480464CTDDiethylstilbestrol affects the reaction [MIR30A mRNA affects the expression of BECN1 mRNA]; Diethylstilbestrol affects the reaction [MIR30A mRNA affects the expression of BECN1 protein]PMID:30153466
Becn1increases expressionISOBecn1 (Rattus norvegicus)6480464CTDDiethylstilbestrol results in increased expression of BECN1 mRNAPMID:37077353
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