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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735631
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP11A1
Name: cytochrome P450 family 11 subfamily A member 1
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: A polyphenol that has formula C18H20O2.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDiethylstilbestrol results in decreased expression of CYP11A1 mRNA

PMID:12858341
decreases expressionISORGD:693256480464CTDDiethylstilbestrol results in decreased expression of CYP11A1 mRNA, Diethylstilbestrol results in decreased expression of CYP11A1 protein

PMID:22615892, PMID:23873838
decreases expressionISORGD:7356326480464CTDDiethylstilbestrol results in decreased expression of CYP11A1 mRNA, Diethylstilbestrol results in decreased expression of CYP11A1 protein

PMID:22100434, PMID:28970132
increases expressionISORGD:7356326480464CTDDiethylstilbestrol results in increased expression of CYP11A1 mRNA

PMID:14648872
multiple interactionsISORGD:693256480464CTD[Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of 17-alpha-Hydroxyprogesterone, [Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Androstenedione, [Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased abundance of Progesterone, [Diethylstilbestrol results in decreased expression of CYP11A1 protein] which results in decreased chemical synthesis of Pregnenolone

PMID:23873838
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.