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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69168
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARG
Name: peroxisome proliferator activated receptor gamma
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGincreases activityISOPparg (Mus musculus)6480464CTDDiethylstilbestrol results in increased activity of PPARG proteinPMID:22710028
PPARGincreases expressionISOPparg (Mus musculus)6480464CTDDiethylstilbestrol results in increased expression of PPARG mRNA; Diethylstilbestrol results in increased expression of PPARG proteinPMID:22710028
PPARGmultiple interactionsISOPparg (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Diethylstilbestrol results in increased expression of PPARG protein]; [troglitazone co-treated with Diethylstilbestrol] results in increased expression of PPARG protein; Diethylstilbestrol inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in increased activity of PPARG protein]; fulvestrant inhibits the reaction [Diethylstilbestrol results in increased activity of PPARG protein]PMID:22710028 PMID:26944108
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