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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10551
Species: Mus musculus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1 (alpha)
Acc ID: CHEBI:41922
Term: diethylstilbestrol
Definition: An olefinic compound that is trans-hex-3-ene in which the hydrogens at positions 3 and 4 have been replaced by p-hydroxyphenyl groups.
Chemical ID: MESH:D004054
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects activityEXP 6480464CTDDiethylstilbestrol affects the activity of ESR1 proteinPMID:16468032 PMID:23611293
Esr1affects bindingEXP 6480464CTDDiethylstilbestrol binds to ESR1 proteinPMID:11162928 PMID:19913605
Esr1affects response to substanceEXP 6480464CTDESR1 protein affects the susceptibility to DiethylstilbestrolPMID:15458790 PMID:22275727 PMID:24316720
Esr1decreases expressionEXP 6480464CTDDiethylstilbestrol results in decreased expression of ESR1 mRNA; Diethylstilbestrol results in decreased expression of ESR1 proteinPMID:14871586 PMID:15082075 PMID:17213693
Esr1increases activityEXP 6480464CTDDiethylstilbestrol results in increased activity of ESR1 proteinPMID:26944108
Esr1increases expressionEXP 6480464CTDDiethylstilbestrol results in increased expression of ESR1 mRNA; Diethylstilbestrol results in increased expression of ESR1 proteinPMID:15070830 PMID:15082075 PMID:22710028 PMID:22733484
Esr1increases response to substanceEXP 6480464CTDESR1 protein mutant form results in increased susceptibility to Diethylstilbestrol; ESR1 results in increased susceptibility to DiethylstilbestrolPMID:22989549 PMID:9290700
Esr1multiple interactionsEXP 6480464CTD[[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] co-treated with Diethylstilbestrol] results in decreased activity of ESR1 protein; [Diethylstilbestrol co-treated with sodium arsenite] results in increased expression of ESR1 protein; [sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of ESR1 mRNA; [sodium arsenite co-treated with Diethylstilbestrol] results in increased expression of ESR1 protein; Diethylstilbestrol binds to and affects the folding of ESR1 protein mutant form; Diethylstilbestrol binds to and results in increased activity of ESR1 protein; ESR1 mutant form inhibits the reaction [Diethylstilbestrol affects the methylation of LTF promoter]; ESR1 mutant form inhibits the reaction [Diethylstilbestrol affects the methylation of SVS4 promoter]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of AR protein]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA10 mRNA]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of HOXA11 mRNA]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of SVS4 mRNA]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of SVS4 protein]; ESR1 protein affects the reaction [Diethylstilbestrol results in decreased expression of WNT7A mRNA]; ESR1 protein affects the reaction [Diethylstilbestrol results in increased expression of LTF]; ESR1 protein promotes the reaction [Diethylstilbestrol results in increased phosphorylation of and results in increased activity of IGF1R protein]; fulvestrant inhibits the reaction [Diethylstilbestrol results in increased activity of ESR1 protein]PMID:10965916 PMID:15458790 PMID:15465114 PMID:16452187 PMID:16712894 PMID:19665456 PMID:22275727 PMID:24316720 PMID:26944108 PMID:27721470
Esr1affects activityISOEsr1 (Rattus norvegicus)6480464CTDDiethylstilbestrol affects the activity of ESR1 proteinPMID:15746884
Esr1affects bindingISOEsr1 (Rattus norvegicus)6480464CTDDiethylstilbestrol binds to ESR1 proteinPMID:15204698 PMID:19913605
Esr1affects bindingISOESR1 (Homo sapiens)6480464CTD[Diethylstilbestrol binds to ESR1 protein] which binds to NCOA2 protein; Diethylstilbestrol binds to ESR1 proteinPMID:10964929 PMID:11162928 PMID:11354909 PMID:11518614 PMID:11823001 PMID:12598185 PMID:12818366 PMID:15123288 PMID:15253041 PMID:15521089 PMID:17287592 PMID:17400923 PMID:17559906 PMID:19913605 PMID:20074635 PMID:28280777 PMID:30143207 PMID:9751507
Esr1affects expressionISOEsr1 (Rattus norvegicus)6480464CTDDiethylstilbestrol affects the expression of ESR1 mRNA; Diethylstilbestrol affects the expression of ESR1 mRNA alternative form; Diethylstilbestrol affects the expression of ESR1 proteinPMID:17592034 PMID:19696011
Esr1affects response to substanceISOEsr1 (Rattus norvegicus)6480464CTDESR1 protein affects the susceptibility to DiethylstilbestrolPMID:23620786
Esr1affects response to substanceISOESR1 (Homo sapiens)6480464CTDESR1 mRNA affects the susceptibility to DiethylstilbestrolPMID:19492024
Esr1decreases expressionISOEsr1 (Rattus norvegicus)6480464CTDDiethylstilbestrol results in decreased expression of ESR1 mRNA; Diethylstilbestrol results in decreased expression of ESR1 proteinPMID:11108262 PMID:21285323
Esr1increases activityISOEsr1 (Rattus norvegicus)6480464CTDDiethylstilbestrol results in increased activity of ESR1 proteinPMID:17174995
Esr1increases activityISOESR1 (Homo sapiens)6480464CTDDiethylstilbestrol results in increased activity of ESR1 proteinPMID:11331656 PMID:17141713 PMID:19161236 PMID:21543282 PMID:9846162
Esr1increases expressionISOEsr1 (Rattus norvegicus)6480464CTDDiethylstilbestrol results in increased expression of ESR1 mRNA; Diethylstilbestrol results in increased expression of ESR1 proteinPMID:11108262 PMID:11748029 PMID:14749301 PMID:15855622 PMID:22198180
Esr1increases expressionISOESR1 (Homo sapiens)6480464CTDDiethylstilbestrol results in increased expression of ESR1 mRNAPMID:29883470 PMID:32088792
Esr1multiple interactionsISOEsr1 (Rattus norvegicus)6480464CTDDiethylstilbestrol inhibits the reaction [[Estradiol co-treated with Progesterone] results in increased expression of ESR1 protein]; Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein]PMID:15204698 PMID:18653720
Esr1multiple interactionsISOESR1 (Homo sapiens)6480464CTD[Diethylstilbestrol co-treated with ESR1 protein] results in increased expression of LTF mRNA; Diethylstilbestrol analog binds to and results in increased activity of ESR1 protein; Diethylstilbestrol binds to and results in decreased activity of ESR1 protein; Diethylstilbestrol binds to and results in increased activity of ESR1 protein; Diethylstilbestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein]; Diethylstilbestrol inhibits the reaction [Coumestrol binds to ESR1 protein]; Diethylstilbestrol inhibits the reaction [Estradiol binds to ESR1 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to CREBBP protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to EZH2 promoter]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to HOTAIR promoter]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to HOXA10 promoter]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to ILK protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to MED1 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA1 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA2 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA3 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NCOA6 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NR0B1 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NR0B2 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NRIP1 protein mutant form]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to NRIP1 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to PNRC1 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to PPARGC1A protein]; Diethylstilbestrol promotes the reaction [ESR1 protein binds to TRIM24 protein]; Diethylstilbestrol promotes the reaction [ESR1 protein modified form binds to NCOA1 protein modified form]; Diethylstilbestrol promotes the reaction [NCOA2 protein binds to ESR1 protein]; Diethylstilbestrol results in increased activity of and affects the localization of ESR1 protein; ESR1 protein promotes the reaction [Diethylstilbestrol results in increased expression of HOTAIR mRNA]; Fulvestrant inhibits the reaction [Diethylstilbestrol binds to and results in increased activity of ESR1 protein]PMID:10397250 PMID:10964929 PMID:11354909 PMID:11465389 PMID:11823001 PMID:12127041 PMID:12579585 PMID:12765243 PMID:12818366 PMID:15084758 PMID:15120416 PMID:15236964 PMID:17559906 PMID:18028983 PMID:20362049 PMID:20435135 PMID:21256200 PMID:21783566 PMID:23383871 PMID:24533973 PMID:24548648 PMID:25012808 PMID:25088689 PMID:26865669 PMID:29162470 PMID:30143207 PMID:30896932 PMID:32088792 PMID:33049310 PMID:9048584 PMID:9751507
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