GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ifng | decreases expression | EXP | | 6480464 | CTD | Dexamethasone results in decreased expression of IFNG protein | PMID:12504806 PMID:12760963 PMID:19997594 | Ifng | increases expression | EXP | | 6480464 | CTD | Dexamethasone results in increased expression of IFNG mRNA; Dexamethasone results in increased expression of IFNG protein | PMID:22842586 | Ifng | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of IFNG mRNA; Dexamethasone inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Dexamethasone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Dexamethasone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IFNG mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Dexamethasone inhibits the reaction [Ovalbumin results in decreased secretion of IFNG protein]; Dexamethasone inhibits the reaction [Oxazolone results in increased expression of IFNG protein]; DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of IFNG protein] | PMID:12504806 PMID:12612912 PMID:12794164 PMID:16880258 PMID:18670081 PMID:21951872 PMID:22185406 PMID:27568862 PMID:31751647 PMID:33203037 PMID:36350155 | Ifng | decreases expression | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Dexamethasone results in decreased expression of IFNG mRNA; Dexamethasone results in decreased expression of IFNG protein | PMID:10596698 PMID:10883730 PMID:16045733 PMID:9743329 | Ifng | decreases secretion | ISO | IFNG (Homo sapiens) | 6480464 | CTD | Dexamethasone results in decreased secretion of IFNG protein | PMID:11692113 PMID:16321374 | Ifng | multiple interactions | ISO | Ifng (Rattus norvegicus) | 6480464 | CTD | Dexamethasone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein] | PMID:12694877 PMID:16782535 PMID:16867261 | Ifng | multiple interactions | ISO | IFNG (Homo sapiens) | 6480464 | CTD | [IFNG protein co-treated with 4,4'-hexafluorisopropylidene diphenol] inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in increased expression of CYCS protein]; [IFNG protein co-treated with 4,4'-hexafluorisopropylidene diphenol] inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in increased expression of HSPD1 protein]; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of IFNG protein]; Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]; Dexamethasone inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; IFNG protein inhibits the reaction [[Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA]; IFNG protein inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with 4,4'-hexafluorisopropylidene diphenol] results in increased expression of UCP1 mRNA]; IFNG protein promotes the reaction [4,4'-hexafluorisopropylidene diphenol inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in decreased expression of IRF1 mRNA]]; IFNG protein promotes the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with 4,4'-hexafluorisopropylidene diphenol] results in increased expression of STAT1 mRNA]; IFNG protein promotes the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in increased expression of STAT1 protein]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]] | PMID:16321374 PMID:16357325 PMID:20363256 PMID:27568862 PMID:31596606 PMID:8568266 | |
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