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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737488
Species: Mus musculus
RGD Object: Gene
Symbol: Ifng
Name: interferon gamma
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ifngdecreases expressionEXP 6480464CTDDexamethasone results in decreased expression of IFNG proteinPMID:12504806 PMID:12760963 PMID:19997594
Ifngincreases expressionEXP 6480464CTDDexamethasone results in increased expression of IFNG mRNA; Dexamethasone results in increased expression of IFNG proteinPMID:22842586
Ifngmultiple interactionsEXP 6480464CTD[bisphenol A co-treated with INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] affects the expression of IFNG mRNA; Dexamethasone inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide]; Dexamethasone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Dexamethasone inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; Dexamethasone inhibits the reaction [[TNF protein co-treated with IFNG protein] results in increased chemical synthesis of Nitric Oxide]; Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IFNG mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; Dexamethasone inhibits the reaction [Ovalbumin results in decreased secretion of IFNG protein]; Dexamethasone inhibits the reaction [Oxazolone results in increased expression of IFNG protein]; DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG mRNA]]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of IFNG protein]PMID:12504806 PMID:12612912 PMID:12794164 PMID:16880258 PMID:18670081 PMID:21951872 PMID:22185406 PMID:27568862 PMID:31751647 PMID:33203037 PMID:36350155
Ifngdecreases expressionISOIFNG (Homo sapiens)6480464CTDDexamethasone results in decreased expression of IFNG mRNA; Dexamethasone results in decreased expression of IFNG proteinPMID:10596698 PMID:10883730 PMID:16045733 PMID:9743329
Ifngdecreases secretionISOIFNG (Homo sapiens)6480464CTDDexamethasone results in decreased secretion of IFNG proteinPMID:11692113 PMID:16321374
Ifngmultiple interactionsISOIfng (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG mRNA]; Dexamethasone inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased expression of IFNG protein]PMID:12694877 PMID:16782535 PMID:16867261
Ifngmultiple interactionsISOIFNG (Homo sapiens)6480464CTD[IFNG protein co-treated with 4,4'-hexafluorisopropylidene diphenol] inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in increased expression of CYCS protein]; [IFNG protein co-treated with 4,4'-hexafluorisopropylidene diphenol] inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in increased expression of HSPD1 protein]; ABCB1 gene polymorphism affects the reaction [Dexamethasone results in decreased secretion of IFNG protein]; Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]; Dexamethasone inhibits the reaction [IFNG results in increased expression of HLA-DRA mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of IFNG protein]; IFNG protein inhibits the reaction [[Dexamethasone co-treated with IL4 protein] results in increased expression of CHID1 mRNA]; IFNG protein inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with 4,4'-hexafluorisopropylidene diphenol] results in increased expression of UCP1 mRNA]; IFNG protein promotes the reaction [4,4'-hexafluorisopropylidene diphenol inhibits the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in decreased expression of IRF1 mRNA]]; IFNG protein promotes the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone co-treated with 4,4'-hexafluorisopropylidene diphenol] results in increased expression of STAT1 mRNA]; IFNG protein promotes the reaction [[INS protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with Rosiglitazone] results in increased expression of STAT1 protein]; Mifepristone inhibits the reaction [Dexamethasone inhibits the reaction [CD28 protein results in increased secretion of IFNG protein]]PMID:16321374 PMID:16357325 PMID:20363256 PMID:27568862 PMID:31596606 PMID:8568266
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