Gene Chemical Interaction Report - Rat Genome Database

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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID:	737448
Species:	Mus musculus
RGD Object:	Gene
Symbol:	Cat
Name:	catalase

Acc ID:	CHEBI:41879
Term:	dexamethasone
Definition:	A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID:	MESH:D003907

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
Cat	decreases activity	EXP		6480464	CTD	Dexamethasone results in decreased activity of CAT protein	PMID:17180084
Cat	decreases expression	EXP		6480464	CTD	Dexamethasone results in decreased expression of CAT mRNA	PMID:17180084
Cat	increases activity	EXP		6480464	CTD	Dexamethasone results in increased activity of CAT protein	PMID:10590836
Cat	multiple interactions	EXP		6480464	CTD	[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CAT mRNA; BCL2 gene inhibits the reaction [Dexamethasone results in decreased activity of CAT protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]; Dexamethasone inhibits the reaction [Paraquat results in increased activity of CAT protein]	PMID:16054899 PMID:17180084 PMID:21801858 PMID:26363199 PMID:37177863
Cat	decreases activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	Dexamethasone results in decreased activity of CAT protein	PMID:11114198 PMID:15895680 PMID:21986892
Cat	decreases expression	ISO	Cat (Rattus norvegicus)	6480464	CTD	Dexamethasone results in decreased expression of CAT mRNA	PMID:17522070
Cat	increases activity	ISO	Cat (Rattus norvegicus)	6480464	CTD	Dexamethasone results in increased activity of CAT protein	PMID:15353912
Cat	increases expression	ISO	Cat (Rattus norvegicus)	6480464	CTD	Dexamethasone results in increased expression of CAT protein	PMID:15965953
Cat	increases expression	ISO	CAT (Homo sapiens)	6480464	CTD	Dexamethasone results in increased expression of CAT mRNA	PMID:25047013
Cat	multiple interactions	ISO	Cat (Rattus norvegicus)	6480464	CTD	[Dexamethasone co-treated with ciprofibrate] results in increased expression of CAT protein; Dexamethasone inhibits the reaction [Lipopolysaccharides results in decreased expression of CAT protein]; Dexamethasone inhibits the reaction [Oleic Acid results in increased activity of CAT protein]	PMID:15965953 PMID:26360969 PMID:37696682
Cat	multiple interactions	ISO	CAT (Homo sapiens)	6480464	CTD	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of CAT mRNA	PMID:28628672

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