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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737323
Species: Homo sapiens
RGD Object: Gene
Symbol: ACE
Name: angiotensin I converting enzyme
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACEdecreases activityISOAce (Rattus norvegicus)6480464CTDDexamethasone results in decreased activity of ACE proteinPMID:1659346 PMID:9498404
ACEincreases expressionISOAce (Mus musculus)6480464CTDDexamethasone results in increased expression of ACE mRNA; Dexamethasone results in increased expression of ACE proteinPMID:22733784 PMID:30940551
ACEincreases expressionISOAce (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of ACE mRNA; Dexamethasone results in increased expression of ACE proteinPMID:15932931 PMID:32494933
ACEmultiple interactionsISOAce (Mus musculus)6480464CTDdiisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [Dexamethasone results in increased expression of ACE protein]; Enalapril inhibits the reaction [diisononyl phthalate promotes the reaction [Dexamethasone results in increased expression of ACE protein]]PMID:30940551
ACEmultiple interactionsISOAce (Rattus norvegicus)6480464CTD[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of ACE protein]; Mifepristone inhibits the reaction [Dexamethasone results in increased expression of ACE mRNA]PMID:15932931 PMID:32494933
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