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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735784
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL3
Name: C-C motif chemokine ligand 3
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL3multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL3 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]PMID:27568862 PMID:36416909
CCL3decreases expressionISOCcl3 (Mus musculus)6480464CTDDexamethasone results in decreased expression of CCL3 proteinPMID:21880982
CCL3multiple interactionsISOCcl3 (Mus musculus)6480464CTDDexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 protein]; DUSP1 gene mutant form inhibits the reaction [Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL3 mRNA]]PMID:16880258 PMID:27568862
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