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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735634
Species: Mus musculus
RGD Object: Gene
Symbol: Scarb1
Name: scavenger receptor class B, member 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scarb1increases expressionEXP 6480464CTDDexamethasone results in increased expression of SCARB1 mRNAPMID:21041162
Scarb1affects expressionISOScarb1 (Rattus norvegicus)6480464CTDDexamethasone affects the expression of SCARB1 mRNA; Dexamethasone affects the expression of SCARB1 proteinPMID:32234517
Scarb1decreases expressionISOScarb1 (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of SCARB1 mRNA; Dexamethasone results in decreased expression of SCARB1 proteinPMID:12475377 PMID:33983380
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