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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735512
Species: Homo sapiens
RGD Object: Gene
Symbol: MCL1
Name: MCL1 apoptosis regulator, BCL2 family member
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MCL1increases expressionEXP 6480464CTDDexamethasone results in increased expression of MCL1 mRNAPMID:16144937
MCL1increases expressionISOMcl1 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of MCL1 mRNAPMID:20032058
MCL1multiple interactionsISOMcl1 (Rattus norvegicus)6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of MCL1 mRNA]PMID:20032058
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