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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734247
Species: Mus musculus
RGD Object: Gene
Symbol: Tnfrsf1a
Name: tumor necrosis factor receptor superfamily, member 1a
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tnfrsf1aincreases expressionEXP 6480464CTDDexamethasone results in increased expression of TNFRSF1A mRNAPMID:21041162
Tnfrsf1amultiple interactionsEXP 6480464CTD[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein; [IL10 protein co-treated with Dexamethasone] inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]; boric acid inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of TNFRSF1A protein]; sodium pentaborate inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS protein] results in increased expression of TNFRSF1A protein]PMID:28285642 PMID:37177863
Tnfrsf1adecreases expressionISOTnfrsf1a (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of TNFRSF1A mRNAPMID:17522070
Tnfrsf1amultiple interactionsISOTNFRSF1A (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of TNFRSF1A mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of TNFRSF1A mRNAPMID:28628672
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