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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733187
Species: Homo sapiens
RGD Object: Gene
Symbol: ACO2
Name: aconitase 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACO2decreases expressionISOAco2 (Mus musculus)6480464CTDDexamethasone results in decreased expression of ACO2 proteinPMID:33567340
ACO2decreases expressionISOAco2 (Rattus norvegicus)6480464CTDDexamethasone results in decreased expression of ACO2 mRNAPMID:20032058
ACO2multiple interactionsISOAco2 (Mus musculus)6480464CTD[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein] results in increased expression of ACO2 mRNA; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of ACO2 mRNAPMID:23428407 PMID:24848799
ACO2multiple interactionsISOAco2 (Rattus norvegicus)6480464CTDTestosterone inhibits the reaction [Dexamethasone results in decreased expression of ACO2 mRNA]PMID:20032058
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