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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 731691
Species: Mus musculus
RGD Object: Gene
Symbol: Cx3cl1
Name: C-X3-C motif chemokine ligand 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cx3cl1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of CX3CL1 mRNAPMID:22733784
Cx3cl1increases expressionEXP 6480464CTDDexamethasone results in increased expression of CX3CL1 mRNAPMID:21041162
Cx3cl1multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA; [Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA; Tetrachlorodibenzodioxin promotes the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CX3CL1 mRNA]; TNF protein promotes the reaction [[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CX3CL1 mRNA]PMID:16054899 PMID:23503329
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