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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69287
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sqstm1
Name: sequestosome 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sqstm1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of SQSTM1 proteinPMID:33359579
Sqstm1decreases expressionISOSQSTM1 (Homo sapiens)6480464CTDDexamethasone results in decreased expression of SQSTM1 proteinPMID:33359579
Sqstm1multiple interactionsISOSQSTM1 (Homo sapiens)6480464CTD5-amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid inhibits the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]; [Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] affects the expression of SQSTM1 protein; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SQSTM1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of SQSTM1 mRNA; bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]; Sirolimus promotes the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]PMID:23111315 PMID:28628672 PMID:33359579
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