GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cdkn1b | multiple interactions | EXP | | 6480464 | CTD | 5,7-dihydroxy-2-methyl-8-(4-(3-hydroxy-1-methyl)-piperidinyl)-4H-1-benzopyran-4-one inhibits the reaction [[INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of CDKN1B protein]; [1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein; [Acrylamide co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein; [INS1 protein co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone] results in decreased expression of CDKN1B protein; Silybin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CDKN1B protein] | PMID:24646949 PMID:25559859 PMID:30409764 | Cdkn1b | decreases expression | ISO | Cdkn1b (Rattus norvegicus) | 6480464 | CTD | Dexamethasone results in decreased expression of CDKN1B mRNA; Dexamethasone results in decreased expression of CDKN1B protein | PMID:34537908 | Cdkn1b | decreases expression | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | Dexamethasone results in decreased expression of CDKN1B mRNA; Dexamethasone results in decreased expression of CDKN1B protein | PMID:34537908 | Cdkn1b | increases expression | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | Dexamethasone results in increased expression of CDKN1B mRNA; Dexamethasone results in increased expression of CDKN1B protein | PMID:19428934 | Cdkn1b | multiple interactions | ISO | Cdkn1b (Rattus norvegicus) | 6480464 | CTD | [Polyribonucleotides results in decreased expression of MIR17 mRNA] inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B mRNA]; [Polyribonucleotides results in decreased expression of MIR17 mRNA] inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B protein]; Dexamethasone inhibits the reaction [FOXL2 protein binds to CDKN1B promoter] | PMID:34537908 | Cdkn1b | multiple interactions | ISO | CDKN1B (Homo sapiens) | 6480464 | CTD | [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of CDKN1B mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of CDKN1B mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of CDKN1B mRNA; [Polyribonucleotides results in decreased expression of MIR17 mRNA] inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B mRNA]; [Polyribonucleotides results in decreased expression of MIR17 mRNA] inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B protein]; Dexamethasone inhibits the reaction [FOXL2 protein binds to CDKN1B promoter]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B mRNA]; Mifepristone inhibits the reaction [Dexamethasone results in decreased expression of CDKN1B protein] | PMID:28628672 PMID:34537908 | | ||||||||||||||||||||||
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