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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69038
Species: Homo sapiens
RGD Object: Gene
Symbol: IGFBP1
Name: insulin like growth factor binding protein 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IGFBP1multiple interactionsEXP 6480464CTD[Dexamethasone results in increased phosphorylation of and results in increased activity of NR3C1 protein] which results in increased expression of IGFBP1 mRNA; Dexamethasone promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of IGFBP1 mRNA]PMID:18483179 PMID:23275455
IGFBP1increases expressionISOIgfbp1 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of IGFBP1 mRNAPMID:17522070
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