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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 68328
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc2a5
Name: solute carrier family 2 member 5
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc2a5affects expressionEXP 6480464CTDDexamethasone affects the expression of SLC2A5 mRNAPMID:15102944
Slc2a5increases expressionEXP 6480464CTDDexamethasone results in increased expression of SLC2A5 mRNAPMID:20032058
Slc2a5multiple interactionsEXP 6480464CTDDexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]; Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased activity of SLC2A5 protein]]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [Fructose results in increased expression of SLC2A5 mRNA]]; Testosterone inhibits the reaction [Dexamethasone results in increased expression of SLC2A5 mRNA]PMID:18556366 PMID:20032058
Slc2a5multiple interactionsISOSLC2A5 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of SLC2A5 mRNAPMID:28628672
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