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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 67390
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Orm1
Name: orosomucoid 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Orm1increases expressionEXP 6480464CTDDexamethasone results in increased expression of ORM1 mRNAPMID:15661831 PMID:20599767
Orm1multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with IL6 protein] results in increased expression of ORM1 mRNA; CEBPB protein inhibits the reaction [PPARA protein inhibits the reaction [Dexamethasone results in increased expression of ORM1 mRNA]]; Cycloheximide inhibits the reaction [Dexamethasone results in increased expression of ORM1 mRNA]; pirinixic acid inhibits the reaction [[Dexamethasone co-treated with IL6 protein] results in increased expression of ORM1 mRNA]; pirinixic acid inhibits the reaction [Dexamethasone results in increased expression of ORM1 mRNA]; PPARA protein inhibits the reaction [Dexamethasone results in increased expression of ORM1 mRNA]PMID:15661831 PMID:20599767
Orm1increases expressionISOOrm1 (Mus musculus)6480464CTDDexamethasone results in increased expression of ORM1 mRNAPMID:22733784
Orm1multiple interactionsISOOrm1 (Mus musculus)6480464CTD[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA; EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ORM1 mRNA]PMID:16054899
Orm1multiple interactionsISOORM1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ORM1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in decreased expression of ORM1 mRNAPMID:28628672
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