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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621282
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Birc3
Name: baculoviral IAP repeat-containing 3
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Birc3increases expressionEXP 6480464CTDDexamethasone results in increased expression of BIRC3 mRNAPMID:20032058
Birc3multiple interactionsEXP 6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of BIRC3 mRNA]PMID:20032058
Birc3increases expressionISOBIRC3 (Homo sapiens)6480464CTDDexamethasone results in increased expression of BIRC3 mRNA; Dexamethasone results in increased expression of BIRC3 proteinPMID:12782123 PMID:16144937 PMID:9374718
Birc3multiple interactionsISOBIRC3 (Homo sapiens)6480464CTDDexamethasone inhibits the reaction [TNF protein results in decreased expression of BIRC3 protein]PMID:11399663
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