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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620865
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Lif
Name: LIF, interleukin 6 family cytokine
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lifdecreases expressionISOLIF (Homo sapiens)6480464CTDDexamethasone results in decreased expression of LIF mRNAPMID:25047013 PMID:25136773
Lifmultiple interactionsISOLIF (Homo sapiens)6480464CTD[Dexamethasone co-treated with 8-Bromo Cyclic Adenosine Monophosphate co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of LIF mRNA; [Dexamethasone co-treated with Genistein] results in decreased expression of LIF mRNAPMID:16997883 PMID:25136773
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