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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 61312
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Timp2
Name: TIMP metallopeptidase inhibitor 2
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Timp2decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of TIMP2 mRNAPMID:20032058
Timp2multiple interactionsEXP 6480464CTDTestosterone inhibits the reaction [Dexamethasone results in decreased expression of TIMP2 mRNA]PMID:20032058
Timp2multiple interactionsISOTimp2 (Mus musculus)6480464CTD[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with Rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of TIMP2 mRNA]PMID:16054899
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