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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3933
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ucp3
Name: uncoupling protein 3
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ucp3increases expressionEXP 6480464CTDDexamethasone results in increased expression of UCP3 mRNAPMID:17884810
Ucp3multiple interactionsEXP 6480464CTDEP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]; HDAC1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]; resveratrol inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]; SIRT1 protein inhibits the reaction [Dexamethasone results in increased expression of UCP3 mRNA]; SIRT1 protein inhibits the reaction [EP300 protein promotes the reaction [Dexamethasone results in increased expression of UCP3 mRNA]]PMID:17884810
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