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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3087
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mgmt
Name: O-6-methylguanine-DNA methyltransferase
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mgmtincreases activityISOMgmt (Mus musculus)6480464CTDDexamethasone results in increased activity of MGMT proteinPMID:20308330
Mgmtincreases expressionISOMgmt (Mus musculus)6480464CTDDexamethasone results in increased expression of MGMT mRNAPMID:20308330
Mgmtincreases expressionISOMGMT (Homo sapiens)6480464CTDDexamethasone results in increased expression of MGMT mRNAPMID:15481722 PMID:29164620
Mgmtmultiple interactionsISOMgmt (Mus musculus)6480464CTDMifepristone inhibits the reaction [Dexamethasone results in increased expression of MGMT mRNA]PMID:20308330
Mgmtmultiple interactionsISOMGMT (Homo sapiens)6480464CTD[Nimustine co-treated with Dexamethasone] results in increased expression of MGMT mRNA; Dexamethasone promotes the reaction [MGMT protein results in decreased susceptibility to Nimustine]PMID:15481722
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