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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2834
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Hsd11b1
Name: hydroxysteroid 11-beta dehydrogenase 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hsd11b1affects expressionEXP 6480464CTDDexamethasone affects the expression of HSD11B1 mRNAPMID:15102944
Hsd11b1increases expressionISOHsd11b1 (Mus musculus)6480464CTDDexamethasone results in increased expression of HSD11B1 mRNAPMID:19344079 PMID:22733784
Hsd11b1increases expressionISOHSD11B1 (Homo sapiens)6480464CTDDexamethasone results in increased expression of HSD11B1 mRNAPMID:19853017
Hsd11b1multiple interactionsISOHSD11B1 (Homo sapiens)6480464CTD[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of HSD11B1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol S] results in increased expression of HSD11B1 mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of HSD11B1 mRNA; Dexamethasone results in increased expression of and results in increased activity of HSD11B1 protein; NR3C1 protein affects the reaction [Dexamethasone results in increased expression of and results in increased activity of HSD11B1 protein]; Rosiglitazone inhibits the reaction [[Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine] results in decreased expression of HSD11B1 mRNA]PMID:19186324 PMID:20922465 PMID:28628672
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