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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2118
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Anxa1
Name: annexin A1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Anxa1affects response to substanceEXP 6480464CTDANXA1 protein affects the susceptibility to DexamethasonePMID:15472012
Anxa1affects response to substanceISOAnxa1 (Mus musculus)6480464CTDANXA1 protein affects the susceptibility to DexamethasonePMID:12475898
Anxa1increases expressionISOANXA1 (Homo sapiens)6480464CTDDexamethasone results in increased expression of ANXA1 proteinPMID:10807665
Anxa1increases localizationISOANXA1 (Homo sapiens)6480464CTDDexamethasone results in increased localization of ANXA1 protein modified formPMID:10807665
Anxa1increases phosphorylationISOANXA1 (Homo sapiens)6480464CTDDexamethasone results in increased phosphorylation of ANXA1 proteinPMID:10807665
Anxa1multiple interactionsISOAnxa1 (Mus musculus)6480464CTDANXA1 protein affects the susceptibility to [Dexamethasone co-treated with Carrageenan]PMID:12475898
Anxa1multiple interactionsISOANXA1 (Homo sapiens)6480464CTD4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Dexamethasone results in increased phosphorylation of ANXA1 protein]; ANXA1 protein inhibits the reaction [Dexamethasone results in decreased susceptibility to CXCL8 protein]; Dexamethasone promotes the reaction [EGFR protein binds to ANXA1 protein modified form]; Mifepristone inhibits the reaction [Dexamethasone promotes the reaction [EGFR protein binds to ANXA1 protein modified form]]; Mifepristone inhibits the reaction [Dexamethasone results in increased localization of ANXA1 protein modified form]; Mifepristone inhibits the reaction [Dexamethasone results in increased phosphorylation of and results in increased expression of ANXA1 protein]PMID:10807665 PMID:7522859
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