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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1605729
Species: Homo sapiens
RGD Object: Gene
Symbol: HMGB1
Name: high mobility group box 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMGB1multiple interactionsEXP 6480464CTD[Ascorbic Acid co-treated with beta-glycerophosphoric acid co-treated with Dexamethasone] results in decreased expression of HMGB1 mRNAPMID:26424790
HMGB1increases expressionISOHmgb1 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of HMGB1 mRNA; Dexamethasone results in increased expression of HMGB1 proteinPMID:32494933
HMGB1multiple interactionsISOHmgb1 (Rattus norvegicus)6480464CTD[Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; [Lithium Chloride co-treated with Pilocarpine] affects the reaction [Dexamethasone results in increased expression of HMGB1 protein]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 mRNA]; Enalaprilat inhibits the reaction [Dexamethasone results in increased expression of HMGB1 protein]PMID:32494933
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