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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1604061
Species: Homo sapiens
RGD Object: Gene
Symbol: CCL5
Name: C-C motif chemokine ligand 5
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CCL5multiple interactionsEXP 6480464CTDDexamethasone inhibits the reaction [[Toluene 2,4-Diisocyanate binds to ALB protein] which results in increased expression of CCL5 protein]; Dexamethasone inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 protein]PMID:16908450 PMID:27568862
CCL5increases expressionISOCcl5 (Mus musculus)6480464CTDDexamethasone results in increased expression of CCL5 mRNAPMID:21041162
CCL5multiple interactionsISOCcl5 (Rattus norvegicus)6480464CTDDexamethasone inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Dexamethasone inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]PMID:18083043
CCL5multiple interactionsISOCcl5 (Mus musculus)6480464CTD[Zinc co-treated with Nickel co-treated with Cobalt co-treated with 1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in decreased expression of CCL5 mRNA; Dexamethasone inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CCL5 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CCL5 mRNA]; Dexamethasone inhibits the reaction [TNF protein results in increased expression of CCL5 protein]PMID:10495789 PMID:23503329 PMID:31751647
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