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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552867
Species: Mus musculus
RGD Object: Gene
Symbol: Per1
Name: period circadian clock 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Per1increases expressionEXP 6480464CTDDexamethasone results in increased expression of PER1 mRNAPMID:22733784 PMID:29229235 PMID:29624291
Per1multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PER1 mRNAPMID:16054899
Per1increases expressionISOPER1 (Homo sapiens)6480464CTDDexamethasone results in increased expression of PER1 mRNA; Dexamethasone results in increased expression of PER1 proteinPMID:15679045 PMID:25047013 PMID:25136773
Per1increases expressionISOPer1 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of PER1 mRNAPMID:20032058
Per1multiple interactionsISOPER1 (Homo sapiens)6480464CTD[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of PER1 mRNAPMID:28628672
Per1multiple interactionsISOPer1 (Rattus norvegicus)6480464CTDTestosterone inhibits the reaction [Dexamethasone results in increased expression of PER1 mRNA]PMID:20032058
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