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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of UGT1A1 mRNA

PMID:19144771
increases expressionEXP 6480464CTDDexamethasone results in increased expression of UGT1A1 mRNA

PMID:21041162, PMID:29222744
multiple interactionsEXP 6480464CTD[Dexamethasone co-treated with Ibuprofen] results in increased expression of UGT1A1 mRNA, Dexamethasone promotes the reaction [Pregnenolone Carbonitrile results in increased expression of UGT1A1 mRNA], Dexamethasone promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of UGT1A1 mRNA]

PMID:16155002, PMID:29222744
increases expressionISORGD:13500186480464CTDDexamethasone results in increased expression of UGT1A1 mRNA, Dexamethasone results in increased expression of UGT1A1 protein

PMID:15557560, PMID:15560369
increases expressionISORGD:39356480464CTDDexamethasone results in increased expression of UGT1A1 mRNA

PMID:15102944, PMID:20607812
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.