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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11452
Species: Mus musculus
RGD Object: Gene
Symbol: Trh
Name: thyrotropin releasing hormone
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Trhincreases expressionISORGD:39036480464CTDDexamethasone results in increased expression of TRH protein

PMID:9681491
Trhmultiple interactionsISORGD:39036480464CTDDexamethasone promotes the reaction [Disulfiram results in decreased expression of TRH protein]

PMID:9681491
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