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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10697
Species: Mus musculus
RGD Object: Gene
Symbol: Gstm1
Name: glutathione S-transferase, mu 1
Acc ID: CHEBI:41879
Term: dexamethasone
Definition: A fluorinated steroid that is 9-fluoropregna-1,4-diene substituted by hydroxy groups at positions 11, 17 and 21, a methyl group at position 16 and oxo groups at positions 3 and 20. It is a synthetic member of the class of glucocorticoids.
Chemical ID: MESH:D003907
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gstm1decreases expressionEXP 6480464CTDDexamethasone results in decreased expression of GSTM1 proteinPMID:33567340
Gstm1increases expressionEXP 6480464CTDDexamethasone results in increased expression of GSTM1 mRNAPMID:21041162 PMID:22733784
Gstm1decreases response to substanceISOGSTM1 (Homo sapiens)6480464CTDGSTM1 protein results in decreased susceptibility to DexamethasonePMID:20067466
Gstm1increases expressionISOGstm1 (Rattus norvegicus)6480464CTDDexamethasone results in increased expression of GSTM1 mRNAPMID:11328961 PMID:1394205
Gstm1multiple interactionsISOGSTM1 (Homo sapiens)6480464CTDGSTM1 protein inhibits the reaction [Dexamethasone results in increased phosphorylation of BCL2L11 protein]PMID:20067466
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