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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 737520
Species: Mus musculus
RGD Object: Gene
Symbol: Cyp19a1
Name: cytochrome P450, family 19, subfamily a, polypeptide 1
Acc ID: CHEBI:41774
Term: tamoxifen
Definition: A stilbenoid that has formula 371.51460.
Chemical ID: MESH:D013629
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cyp19a1decreases expressionISOCYP19A1 (Homo sapiens)6480464CTDTamoxifen results in decreased expression of CYP19A1 mRNAPMID:10704911 PMID:21296134
Cyp19a1increases expressionISOCYP19A1 (Homo sapiens)6480464CTDTamoxifen analog results in increased expression of CYP19A1 mRNAPMID:19549922
Cyp19a1multiple interactionsISOCYP19A1 (Homo sapiens)6480464CTD[Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA; [Tamoxifen inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]] which results in decreased chemical synthesis of aflatoxicol; Tamoxifen inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]; Tamoxifen inhibits the reaction [diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]]; Tamoxifen inhibits the reaction [ESR1 protein binds to CYP19A1 promoter]PMID:19059307 PMID:21296134 PMID:24994688
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