GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Cyp19a1 | decreases expression | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | Tamoxifen results in decreased expression of CYP19A1 mRNA | PMID:10704911 PMID:21296134 | Cyp19a1 | increases expression | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | Tamoxifen analog results in increased expression of CYP19A1 mRNA | PMID:19549922 | Cyp19a1 | multiple interactions | ISO | CYP19A1 (Homo sapiens) | 6480464 | CTD | [Tamoxifen co-treated with ESR2 protein] results in decreased expression of CYP19A1 mRNA; [Tamoxifen inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]] which results in decreased chemical synthesis of aflatoxicol; Tamoxifen inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]; Tamoxifen inhibits the reaction [diethyl phthalate promotes the reaction [ESR1 protein binds to CYP19A1 promoter]]; Tamoxifen inhibits the reaction [ESR1 protein binds to CYP19A1 promoter] | PMID:19059307 PMID:21296134 PMID:24994688 | |
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